… Cutaneous melanoma lesions feature a dense … Melanomas are able to use chemokine
pathways to preferentially recruit cells, which aid their growth, survival, invasion and metastasis, …

… /PD-1 pathway is an attractive option for cancer treatment. As yet, however, the … therapeutic
strategies may form a rationale for achieving better therapeutic options for melanoma patients…

… (TIL) therapy is a type of adoptive cellular therapy by … in vitro with interleukin-2 (IL-2), and
then infused back into the patient [1]. … suppression mediated by the PD pathway at the tumor site …

… therapeutic interventions that enhance T-cell recruitment and, consequently, improved patient
… Results were confirmed in patients treated with immune checkpoint inhibitors using single-…

… twenty transcripts in four functional categories: CXCR3/CCR5 chemokines (including CXCL9,
… activation of these pathways may also improve response to subsequent hormonal therapy. …

We investigated the role of chemokines in regulating T cell accumulation in solid tumors.
CCL5 and CXCL9 overexpression was associated with CD8 + T cell infiltration in solid tumors. …

… In comparison, the average biopsy size obtained from 105 metastatic melanoma patients,
previously treated with TIL ACT at our center, was 24 cm. Despite this constraint, we were able …

… therapies, such as low-dose interleukin-2 (IL-2) treatment … function by targeting specific signal
pathways which are of crucial … The major bottleneck of the Treg adoptive therapy is how to …

… correlated with melanoma patient survival (5), while NK cells in melanoma predicted response
… assessment of tumor-infiltrating lymphocytes in patients receiving adoptive T cell therapy …

… treatment across multiple solid and hematologic malignancies has been revolutionized with
the approval of checkpoint inhibitor therapy (CIT) and adoptive cell therapy … pathways, such …